Lupus nephritis can treat you?

User Question] lupus nephritis treatment? Lupus nephritis is a of nephritis, and whether treatment of lupus nephritis in patients with issues of concern. To address this issue, the following analysis answer.
[The expert answer
Lupus nephritis treatment? Lupus nephritis is a of nephritis, whether treatment of lupus nephritis in patients with issues of concern. To address this issue, the following analysis answer.
Whether the lupus nephritis treatment related to the following points:
Several factors that affect the prognosis of lupus nephritis:
(1) kidney disease type, type I, type II and V-shaped with good prognosis, Type IV the worst prognosis.
(2) the degree of disease activity, the lesion sustained activity or repeated activities prognosis than non-activity case.
(3) the cause, of unknown etiology and poor prognosis, drug-induced lesions improved rapidly by stopping the prognosis is good.
Early targeted treatment is the key, lupus nephritis can treat the problem, the key to the patients found in a timely manner, early detection the prognosis is good, in addition, in the course of treatment should also avoid simple symptomatic treatment . Simple application of large doses of adrenal corticosteroids and immunosuppressive agents, although the prognosis has changed, but can not solve the fundamental problem of recurrent episodes. Treatment should be individualized according to the pathological type of kidney damage and activities, such as small change without special treatment, as long as the amount of hormones that control the systemic manifestations and the corresponding Chinese medicine can give, and diffuse proliferative glomerulonephritis and otherwise actively treatment, Integrative Medicine see good joint therapy.
Three had patients with lupus nephritis will give serious consequences, lupus nephritis, patients can be micro-based medicine penetration therapy for treatment. Timely blocking renal fibrosis, and rescue the injured renal unit, patients with lupus nephritis healthy again.
The above is a good analysis of whether the treatment of lupus nephritis. I hope to be helpful for patients!

What are the symptoms of lupus nephritis early?

[User Question] early symptoms of lupus nephritis? Early lupus nephritis, joint swelling and pain in patients with mostly symmetry. About half of patients with lupus nephritis, morning stiffness, only a few of the relevant section of deformity. Muscle pain, weakness is a common performance. The vast majority of patients with lupus nephritis clinical manifestations of kidney disease, such as proteinuria, hematuria, urinary tube, heavy urine, edema, blood pressure, elevated blood urea nitrogen and creatinine
[The expert answer
What are the early symptoms of lupus nephritis? Early lupus nephritis, joint swelling and pain in patients with mostly symmetry. About half of patients with lupus nephritis, morning stiffness, only a few of the relevant section of deformity. Muscle pain, weakness is a common performance. The vast majority of patients with lupus nephritis clinical manifestations of kidney disease, such as proteinuria, hematuria, urinary tube, heavy urine, edema, blood pressure, blood urea nitrogen and creatinine increased, TCM kidney disease experts tell us, about 1/6 patients with lupus nephritis at the time of diagnosis, there are varying degrees of renal insufficiency. Sometimes it is not typical symptoms of lupus nephritis, only kidney abnormalities are often misdiagnosed as nephritis, nephrotic syndrome or chronic renal failure, such as to miss the best timing of treatment, the condition can not be timely improved, will bring uremia, heart failure or sepsis and other adverse consequences. Therefore, experts have warned that early detection and early treatment.

Chinese medicine treatment of lupus nephritis

Chinese medicine treatment of lupus nephritis, this one of the treatment of lupus nephritis, many people choose western medicine, and in fact this nephropathy is certainly the best in traditional Chinese medicine treatment.
Nephritis is a common disease, the incidence of this disease in the female population is relatively high, recommend that patients must pay attention to the treatment of this disease. For the treatment of lupus nephritis, Western medicine and antibiotics, have a good effect in the short term; TCM Differential Treatment, step by step, very good stability. Patients should take advantage of the strengths of both a reasonable match. TCM treatment of lupus nephritis using the principles of diagnosis and treatment. Chinese medicine cure for lupus nephritis are as follows:
Main symptoms of excessive noxious heat (1): persistent high fever, polydipsia hi cold. Disturbed manic disturbance, and even coma delirium, facial symmetry erythema, color red or subcutaneous erythema, joint pain, with lower extremity edema, or hematuria, flank pain, the tongue red or dark purple, yellow fur, pulse loud or a few strings . The more common type of active lupus nephritis (acute stage). Governing Law: detoxification, cooling blood stasis.
Main symptoms of yin deficiency heat (2): flushing, fat spots, two eyes dry, five upset hot, dry mouth and throat, hair off the teeth shaking, weak waist or pain, or long-term low-grade fever, zygomatic red sweats, dizziness, tinnitus urinate red, dry, to tongue Nenhong little coating or light stripping, rapid pulse. This type is more common in LN subacute phase or mild activity of Governing Law: nourishing yin, cooling blood detoxification prescriptions.

Do very well the prognosis of the patients with lupus nephritis of children

One of lupus nephritis is also a children prone to kidney disease, children with lupus nephritis appears must receive formal treatment, so as not to delay treatment of thedisease, after treatment, the patient is best to do their own prognosis. Active treatment and rehabilitation of their own disease.
Prognosis with the treatment of pediatric lupus nephritis linked, generally after a scientifictreatment, the disease can generally control. A diagnosis, that is needed to treat.Children with systemic lupus erythematosus and fast progress, began to performance formulti-system organ involvement, if not treated, the prognosis is serious.
The prognosis of children with systemic lupus erythematosus depends primarily on thekidneys are involved and the extent of special attention should be.
The treatment plan is individualized, based on children with the severity of the clinical manifestations and different response to therapy, and use the appropriate hormones andimmunosuppressive therapy. The treatment course is long, and is particularly importantto adhere to long-term follow-up and treatment.
In recent years, with the deeper understanding of the disease and diagnosis and treatment of the continuous improvement of prognosis than the past has beensignificantly improved. Systemic lupus erythematosus in children and normal children to college, grow up or even get married and have children.
However, the treatment of systemic lupus erythematosus is a long and arduous processneeds children and their families have a proper understanding of this disease, have enough courage and patience to persist in the long-term follow-up and treatment, this point is very important with children with prognosis the quality are directly related.
The treatment of lupus nephritis in children is very important, diet and health is directly related to the prognosis of lupus in children, parents and friends must bring a high degree of attention, the prognosis of lupus nephritis is still good.

Lupus nephritis should be how to control the diet?

1 patients with lupus nephritis limit salt
Daily salt intake should be controlled in less than 2-4 grams to prevent edema and increased blood volume, and accidents. Patients with hypertension can not be excessive use of sodium, edema, and blood volume, sodium salt of a great relationship. Patients with lupus nephritis, such as eating too much salt, because the disease led to the voiding of kidney function is impaired, often aggravate the symptoms of edema, increased blood volume, resulting in heart failure, it must limit salt, given the low-salt diet.
2 lupus nephritis patients avoid high-fat food
Patients with lupus nephritis accompanied by high blood pressure and symptoms of anemia, because fat can aggravate atherosclerosis, and inhibition of hematopoietic function, animal fats have many adverse effects of the disease, so patients with chronic nephritis should not be too much to eat. However, if the patients had no fat intake, but also caused malnutrition machine experience becomes weaker, so the available vegetable oil instead of in their daily lives, about 60 grams a day.
(3) patients with lupus nephritis limit high purine and high nitrogen food
Because these foods high in purine, nitrogen and high in the renal dysfunction, and its metabolites can not be discharged in time, have a negative impact on renal function.These foods include spinach, celery, radishes, beans, soy products, sardines and chicken soup, fish soup, broth.
4 patients with lupus nephritis avoid using strong spices
Not eat spicy, strong spices pepper, mustard, coffee bile, peppers and other adverse renal function.
Five patients with lupus nephritis limit the amount of fluid of patients with hypertension and edema, to limit the intake of liquids. Lupus nephritis at the onset of kidney function damage does not discharge water in the body, edema of the more serious.
Six patients with lupus nephritis limit plant protein
Lupus nephritis patients to determine the protein intake should be based on the extent of kidney damage. Patients with oliguria, edema, hypertension, and nitrogen mass retention, the daily protein intake should be controlled at 20-40 g, in order to reduce the burden on the kidneys, to avoid the accumulation of non-protein nitrogen in the body.Beans and soy products is a high content of vegetable protein include soybeans, mung beans, soy milk, tofu. Plant proteins containing a lot of fat Yin alkali, can add to the intermediary metabolism of the kidney, it is not appropriate to use the beans and soy products as a nutritional supplement.

The diet of lupus nephritis attention to what matters

The diet of lupus nephritis attention to what matters? Lupus nephritis nephropathy is very serious, the patient must select the appropriate method of active treatment, and control the disease. Proper treatment, is very critical to find the cause. The causes of lupus nephritis What is it? Cause of lupus nephritis. The diet of lupus nephritis attention to what matters
Mostly because of non-standard diet of patients with lupus nephritis. Three meals a day is essential to the daily life of patients with lupus nephritis. For patients with lupus nephritis, follow the dietary guidelines of lupus nephritis is critical, as this will control treatment of lupus nephritis.
[Lupus nephritis the attention]
Systemic lupus erythematosus is a violation of systemic connective tissue autoimmune diseases, lesions involving multiple systems and organs. The disease occurs in young women, the incidence of male to female ratio is about 1:9, the younger, may be more severe the disease, the worse the prognosis. He said that the diet of patients with lupus nephritis need to pay attention to the following:
Spicy spicy food
Like tobacco, alcohol, pepper, raw onions, raw garlic and other spicy spicy food will lead to recurrence or increased symptoms of lupus nephritis.
May induce allergic food
The nephropathy public treatment network expert Zhang, the patients should avoid the fish, shrimp, crabs, etc. may induce food allergies, these can cause disease recurrence or further aggravate.
Of warm meat
Mainly mutton, dog, deer, etc., may cause increased symptoms of patients with lupus nephritis.
[Lupus nephritis to Jichi what]
Hanged sea fishy matter such as fish, shrimp, jellyfish, beef, lamb, Zhu Tourou, onions, leeks, first-class toon. Alfalfa and soybeans, beans, adzuki beans and other legumes, contain L-canavanine, lupus nephritis can deteriorate, it should limit or avoid eating.
Phenylalanine, tyrosine foods that are high, such as beef, not skim milk, etc., so that the role of disease progression, it should be used sparingly or control use, such as the amount of beef per week should be controlled within 100 to 150 g milk every day to control the following 100 to 125 g.
【Patients with lupus nephritis to Yichi what?]
An excessive noxious heat type, should be heat and yin, eat cool food.
Such as watermelon, white chrysanthemum, honeysuckle, Coix Seed, pears, lotus root, wolfberry fruit, wolfberry, Kalimeris, celery, potatoes, tomatoes, melon, banana and so on. Blood (yin) deficiency type, should be qi and nourishing (Yin), to eat food warming (Yin and Blood), such as duck, duck, turtle, American ginseng, astragalus, yams, Coix seed, white beans, walnuts meat, black sesame, wolfberry fruit, longan meat, jujube.
2, the consumption of food containing vitamin A, B6, D and E, rich foods.
Containing foods rich in vitamin A cod liver oil, milk, duck with carotene-rich foods are carrots, corn, sweet potatoes, tomatoes, red berries, cherries, loquats, plums, citrus.Containing vitamin B6.
In addition to diet, lupus nephritis how to treat good?
Micro-based traditional Chinese medicine multi-target therapy first seize lupus nephritis in patients with ischemia and hypoxia, this source of factors that play a role. The active substances of micro-based traditional Chinese medicine into the patient's body, will be targeted location in the injured kidney lesions, play the role of micro-based traditional Chinese medicine treatment of:
Expansion of lupus nephritis in patients with renal artery at all levels, to improve the local microcirculation, the increase in effective renal perfusion to improve the state of impaired renal hypoxia, increasing the local metabolism, accelerate impaired kidney inherent cellular repair, relieve patients with lupus nephritis due to fiber of pathological damage caused by hypertension status.
Micro-based traditional Chinese medicine active substances but also systemic peripheral vascular dilatation in patients with lupus nephritis, improve body microcirculation, promote blood circulation, improve the body due to kidney disease caused by hypoxia, patients with lupus nephritis extrarenal symptoms, especially the skin, relief of symptoms also played a great role in promoting.
Micro-based traditional Chinese medicine active substances can also improve the digestive system microcirculation, alleviate renal fibrosis caused by gastrointestinal mucosal edema, promote increased secretion of digestive juice, and increase appetite.To improve the physical fitness of patients with lupus nephritis, and to create conditions for the further recovery of the disease.

Attention to the diet of lupus nephritis

Lupus nephritis damage to the human body is relatively large, patients in peacetime must pay attention to diet, so you can control the disease progresses. Patients in peacetime must pay attention to prevent the progression of disease or damage to the human body is great, but also more difficult to cure.
Diet of lupus nephritis patients is very important, standardized and reasonable diet can control the disease progresses, patients can be to care more than 50% of lupus patients have kidney damage lupus erythematosus in life in addition to the combination of cold and heat of the clinical syndrome in the actual situation and more food attributes symptomatic selection, but also according to the present material required for the deployment of food. Patients with lupus nephritis protein is often considerable loss of urine caused by hypoproteinemia, edema, and caused a lot of pathological changes of the body, lupus nephritis diet must replenish enough protein. Complementary protein-based animal quality protein such as milk, eggs, lean meat. Appropriate lupus nephritis the amount of lean meat per day per person over 100 grams, not more than two eggs, if the ingestion of excessive, the patient not only can not be completely absorbed, but also increase the burden on the kidney. Nephropathy urinary protein-positive patients, the best Eat or not eat beans and soy products. Clinical perspective, the energy metabolism in patients with disorders, and in the formation of hypoalbuminemia at the same time, some form of hyperlipidemia, especially when the patient is accompanied by fever, digestive function, it is advised to eat light and easily digestible food, should not eat fat-rich meat and fish. Against kidney patients, mostly accompanied by edema, a single hormone therapy, will lead to sodium retention, and therefore to limit the patient's salt intake, given the low-salt, so as not to aggravate symptoms of edema.
Patients with lupus nephritis in the formal treatment, usually have to pay attention to diet, so that the treatment of the disease is very helpful, indeed, lupus nephritis food guidelines for drinking a lot of lupus nephritis patients are concerned about drinking food is good or bad treatment of the disease to some extent. According to the survey showed that lupus nephritis is not only high recurrence rate, and about 20% of patients with lupus nephritis will be 10 years, the development of uremia, one of the leading cause of death in patients with systemic lupus erythematosus. Lupus nephritis diet principles are: patients in the active stage should be light, eat vitamin-rich vegetables and fruits.Patients in remission to those who are asymptomatic, basically eat ordinary drinking food. Kidney damage manifested as oliguria, hypertension, edema, or azotemia should be low-salt low-protein, and limit the intake of water. Until the edema and normal blood pressure, azotemia disappeared, you can eat ordinary food.
The experts pointed out that other treatment of lupus nephritis is critical, patients have to choose a suitable method to heal must be brought under control the disease progresses, focusing on control of disease activity, and stable disease, protect the kidneys. The diagnosis of lupus nephritis, the general said is a systemic lupus erythematosus with kidney damage. It should be said that lupus nephritis activity reflects the activity of systemic lupus erythematosus, the patient will feel aggravated systemic symptoms such as joint pain, hair loss, fever, skin erythema, fatigue, abdominal pain, elevated ESR or other kidney, such as nerve performance of the heart. The most prominent manifestations is a sudden increase in urinary white. Laboratory hematuria or gross hematuria, renal dysfunction, elevated blood urea nitrogen (BUN), creatinine (CR), little or no urine, blood, elevated immunoglobulin antibody increase, hypocomplementemia, renal biopsy pathological changes and so on. Patients as have consciously discomfort, it is timely to find a specialist to check.
Lupus nephritis patients usually must pay attention to diet, do not eat too much, so they will be worse, but we must remember that timely treatment.

Patients with lupus nephritis milk should pay attention to what

Milk is a quality low-protein diet, and nutritious, easily digested and absorbed, and cheap. Patients with lupus nephritis is drinkable. But when drinking milk should also pay attention to the following questions:
[1] The milk should not be prolonged high temperature cooking. By the high temperature, the milk protein by the state of the sol into a gel state, resulting in the emergence of sediment, which reduces the nutritional value. If you like to drink hot milk can be taken to the insulation and heating, fresh bagged milk into the hot water 5 minutes.
[2] Do not drink too much cold milk. Cold milk and may affect gastrointestinal motor function, and cause mild diarrhea, the nutrients in milk can not be completely absorbed.
[3]. Milk is not appropriate for fruit juice and other acidic drinks while drinking. Milk protein, 80% the Los protein, when the milk pH below 4.6, a large number of Los protein will agglutination, precipitation, it is difficult to digest and absorb severe cases can lead to indigestion or diarrhea.
[4] Do not You can drink milk. Because digestion need milk enzyme, fasting milk, milk in the stomach to stay in a very short time, the enzyme can not milk well mixed, the nutrients in the milk time to digest, absorb, and discharged into the large intestine, potentially resulting in waste. Side of drinking the best milk to get something to eat or eating food.
[5]. Within one hour before and after medication Do not drink milk. Milk to form a membrane covering the surface of the drug in the milk of calcium, magnesium and other minerals and drugs to a chemical reaction, thus affecting the efficacy of the release and absorption of milk nutrients is high, the types of minerals in the milk is very rich In addition to the known calcium, phosphorus, iron, zinc, copper, manganese, molybdenum content.The most unusual is that milk is the best source of the body of calcium, and calcium to phosphorus ratio is very appropriate and beneficial to the absorption of calcium. Type of complex is at least 100 kinds of main ingredient is water, fat, phospholipids, protein, lactose, and inorganic salts

Laboratory tests of systemic lupus erythematosus

First, the general inspection
One. Blood can have three lines of pancytopenia
(2) urine proteinuria, hematuria, urinary tube
3 ESR often faster
Second, autoantibodies
(A) anti-nuclear body (ANA) and ANA spectrum
1. The ANA: anti-nuclear antigen composition of autoantibodies general, more than 90% of SLE patients with positive screening test for SLE,; the ANA alternative inspection of LE cells; specific for SLE.
(2) Anti-nucleosome antibody spectrum (ANA spectrum)
ANA by more than 10 types of autoantibodies, become ANA spectra:
Insoluble ingredients (1) anti-nuclear antibody:
1 anti-double stranded DNA antibodies (anti-ds-DNA antibody) specific antibodies in SLE, and its titer correlated with SLE disease activity is positively correlated, anti ds-DNA antibodies may predispose to lupus nephritis
② anti-histone antibodies (AHA): drug-induced lupus more than 95% positive.
(2) soluble ingredients of the anti-nuclear antibody (anti-ENA antibodies) to extractable nuclear antigens (ENA) with saline acidic nuclear protein extracted from the nucleus such as animal liver and spleen. Anti-extractable nuclear antigen antibody called anti-ENA antibodies, the current commercially available anti-ENA antibody test kit includes the following test items:
1 antibody anti-Sm (Smith)
②. Anti-RNP (anti-ribonucleoprotein) antibodies
③ anti-SSA antibody (anti-Ro antibodies)
④ The anti-SSB antibodies (anti-La antibodies)
⑤ The anti-r-RNP (anti-ribosomal) antibody
⑥. Anti-Jo-1 antibody (see Dermatomyositis)
⑦ anti-Scl-70 antibody (see scleroderma)
(B) of antiphospholipid antibodies
(1) anticardiolipin antibody (ACL antibodies)
2 VDRL false-positive
(3) Lupus anticoagulant (LAC)
Antiphospholipid syndrome: seen in habitual abortion, arterial and venous thrombosis and thrombocytopenia
(C) rheumatoid factor (RF): in patients with SLE can be positive
(D) other autoantibodies
An anti-histone antibody (AHA), see above
Anti-RBC membrane antibodies, such as (Coombs, 'test positive)
(3) platelet-associated antibody (PAIgG)
Anti-lymphocyte membrane antibody
Anti-neuronal antibodies - lupus encephalopathy
Third, the complement
Reduce the total complement (CH50) and C3, C4, suggesting lupus activity
Lupus band test (LBT): hair detection by immunofluorescence in the epidermis and dermis of the skin at the junction of the deposition of blue green fluorescence (immunoglobulin)
Renal biopsy: can the diagnosis of SLE can be pathological type
Six other tests (such as head CT lung X-ray plain film heart ultrasound).

Patients with systemic lupus erythematosus pregnancy

Suffering from lupus erythematosus and lupus nephritis if the condition is well controlled and will not affect fertility. Children do not have a big impact. However, patients with lupus nephritis fertility must meet the following two conditions
A lupus activity stabilized
Judgment the seven indicators of lupus activity, including ① arthritis ② The the ANA-positive, decreased complement ③ rash, mucosal ulcers, hair loss, ④ pleurisy, pericarditis ⑤ epilepsy, lupus, headaches, mental disorders (6) vasculitis ⑦ urine changes, such as proteinuria and hematuria. Seven indicators, arthritis, pericarditis, vasculitis, myalgia, brain and kidney damage 3 are known as severe, if not the above performance become stable condition. Patients with lupus nephritis through active treatment, the condition is brought under control, like a normal work, study and life. As for pregnancy, you can consider the case of stable disease activity. Antiphospholipid antibodies and LN patients after pregnancy, abortion is closely related to, should be monitoring.
2, treatment of drug suspension for at least six months or more
Lupus nephritis patients taking hormone drugs and immunosuppressive agents to control the disease, these drugs can cause hormonal disorders in patients, resulting in the decline of women's ability to conceive, and hormone drugs can cause fetal malformations. Pregnancy itself also cause lupus patients with heart and kidney burden increase, induction of disease recurrence.
Patients with lupus nephritis when considering pregnancy, be sure to consider whether their condition is stable lupus nephritis, sustained clinical remission time is long enough, the use of small doses of hormones, immunosuppressants downtime for more than six months of pregnancy in such conditions For patients with lupus nephritis caused by the lowest kidney damage.
Lupus erythematosus have a certain genetic predisposition.
It was found that close relatives of lupus erythematosus incidence rate of 5-12% incidence of dizygotic twin who was 23-69%, indicating that genetic and disease related to the occurrence.
But in clinical practice, we have also seen many lupus patients are children born very healthy, and shall not lupus. For lupus is not hereditary, in fact, the causes of lupus erythematosus, including the result of a variety of integrated factors, including infections, endocrine, and environmental impact should be noted that the clinical findings that mental factors induce a very important cause and aggravate the disease.
Accordingly, only lupus erythematosus have a genetic predisposition, rather than a genetic disease, a clear lupus erythematosus there is no hereditary lupus patients need not worry too much about their own genetic disease would be to their own children.However, to do the best early pregnancy, genetic testing, there are clear of LN loci termination of pregnancy.
Finally: the patients with lupus nephritis should be noted that during the pregnancy
A close attention to the whole pregnancy process
Little attention during pregnancy may lead to disease progression, increased disease activity. In lupus patients during pregnancy be sure to pay close attention to changes in condition and some indicators of change. Deterioration in symptoms to seek medical treatment in a timely manner, follow the doctor's arrangements for the treatment of patients with lupus nephritis must not act arbitrarily.
2, pregnant patients with lupus nephritis should pay attention to proper diet and rest
Patients with lupus nephritis during pregnancy should pay more attention to diet and rest. Reasonable diet to reduce the recurrence rate of induced lupus nephritis, and also conditioning the body. Appropriate rest and avoid fatigue-induced lupus attack.
Summary: patients with lupus nephritis is not absolute, unable to bear children, but need only have a certain physical condition, must not ignore the condition and subjective to determine their own fertility problems, it is best to consult a professional nephrology doctor before making a decision, otherwise easy to produce a variety of pregnancy complications, and even a threat to the safety of patients as well as the life of the fetus.

Systemic lupus erythematosus nephritis therapy

What is the treatment of systemic lupus erythematosus nephritis? Treatment of systemic lupus erythematosus nephritis in addition to the measures of Western medicine, Chinese medicine treatment can take, but the effect is good, then the treatment of systemic lupus erythematosus nephritis, which is also an issue of concern.
Systemic lupus erythematosus nephritis therapy
A TCM treatment of systemic lupus erythematosus nephritis
(1) yin deficiency heat
Main symptoms: facial flushing, fat spots, two eyes dry, five upset hot, dry mouth and throat, hair off the teeth shaking, weak waist or pain, or long-term low-grade fever, the zygomaticus red, night sweats, dizziness, tinnitus, urinate red, dry , tongue Nenhong little moss or light stripping and rapid pulse. This type is more common in systemic lupus erythematosus nephritis subacute stage or mild activity of
Governing Law: nourishing yin, cooling blood detoxification
Recipe: Bai Di Huang Decoction.
Habitat, dogwood, yams, Dan, Poria, Alisma, Anemarrhena, Cork.
Addition and subtraction: low fever night sweats, add Digupi, turtle shell, glehnia; dizziness, tinnitus who added Prunella, abalone, raw keel, raw oyster, the spiritual magnet; weak waist, pain, Kagawa Dipsacus , Eucommia, parasitic, fumarate; water fever, the hematuria add diffusa, Plantago, Health and madder, Rhizoma Imperatae; dry stool, plus Scrophularia, Ophiopogon, Cassia, raw Radix, etc..
(2) excessive noxious heat
Main symptoms: persistent high fever, polydipsia hi cold. Disturbed manic disturbance, and even coma delirium, facial symmetry erythema, color red or subcutaneous erythema, joint pain, with lower extremity edema, or hematuria, flank pain, the tongue red or dark purple, yellow fur, pulse loud or a few strings . The more common type of active nephritis in systemic lupus erythematosus (acute stage).
Governing Law: detoxification, cooling blood stasis.
Recipe: Qingwenbaiduyin decoction.
Gypsum, rhino horn, habitat, Dan, red peony root, Scrophulariaceae, forsythia, Coptis, Scutellaria, mountain gardenia, Anemarrhena, fresh bamboo leaves, bellflower, licorice.
Addition and subtraction: excessive noxious heat, strong heat, thirst, reuse, gypsum, plus honeysuckle, the British public, to the small, Gynura; hematuria obvious, Canada thistle, Burnet, madder, Rhizoma Imperatae; edema, urination poor, plus psyllium, Tuckahoe, Polyporus, Alisma; joint swelling and pain, Ghassan branches, Millettia, papaya, Cyathula, Clematis; coma delirium who was added Gong Niuhuang pills, Zixue class.
(3) spleen deficiency
Main symptoms: two zygomatic erythema dark color, pale white, malaise, chills, weak knees, pay less bloating, loose stools, clear urine, or urine deficient adverse systemic edema below the waist and swollen very pale tongue body fat, with teeth marks, greasy moss, pulse small and weak. Patients with more common clinical manifestations of systemic lupus erythematosus nephritis nephrotic syndrome and systemic lupus erythematosus nephritis, chronic degenerative conditions.
Governing Law: spleen and kidney warming.
Recipe: Jinkuishenqiwan reasonable in the soup and subtraction.
Dry yellow, yam, Cornus, Poria, Alisma, Dan, Cinnamon Twig, aconite, ginseng, ginger, Atractylodes, Licorice.
Addition and subtraction: weak waist, Cabo Delgado Chung, parasitic, Woodwardia; pay less abdominal distention, plus dried tangerine peel, Magnolia, Jian Song, malt; urine, edema compared with fraudulent claims, plus melon skin, Tai Fupi, car before the child, Polyporus.
(4) Qi and Yin
Main symptoms: shortness of breath Shenpi, spontaneous perspiration, palpitations, dizziness, tinnitus, dry mouth and throat, five upset hot, or low-grade fever night sweats, red tongue, weak pulse breakdown. More common in the inactive phase of systemic lupus erythematosus nephritis.
Governing Law: qi and nourishing yin.
Recipe: Shenqidihuang Decoction.
Addition and subtraction: qi deficiency and cold easily, plus service Yupingfengsan; blood deficiency, dizziness, pale lip and a palpitation by, add parsley, polygonum multiflorum, and Placenta; edema, melon skin, Polyporus, car former child; low fever, night sweats, dysphoria heat, plus Digupi, turtle shell, Anemarrhena, Cork; constipation by plus Scrophularia, Ophiopogon, rhubarb; dry mouth and throat by, plus Scrophulariaceae, Dendrobium, Ophiopogon , Polygonatum; Yang and aversion to cold, add Cistanche, Morinda, dodder seed and so on.

Focal glomerulosclerosis clinical classification

FSGS can be idiopathic, can also be common for many different disease end-stagemorphologic features of the so-called "different way to end by".
According to different disease pathogenesis and progression, from the organization
Morphological analysis can be divided into four types:
① peripheral type: periphery of glomerular sclerosis, hardened area often and parietalepithelial cell adhesion, children idiopathic FSGS common to this type;
② mixed type: umbilical of glomerular sclerosis with vascular hyalinization, the lesionsbegan in the vascular pole, adult idiopathic FSGS common of this type;
(3) collapse type: poor glomerular loop open, shrinkage, widely collapse of capillary loops, this type of multi-infection with the virus;
The ④ nodules: mesangial matrix increase, the formation of nodules, often accompanied by afferent arteriole hyalinization, typical morphological changes of diabetic nephropathy.

So how to deal with lupus nephritis the edema?

1, lupus erythematosus patients with only mild edema, you should limit activities, but in terms of patients with severe edema, try not to exercise, more rest.
2, control in patients with fluid and salt intake, if the patient is also associated with renaldysfunction, and try not to eat foods rich in protein.
Accurate records of the patient's drinking, the amount of food, excretion, vomiting volumeand sweat.
4, if the edema in patients with poor feel the skin, low resistance, should be to preventinfection after compression, burns, abrasions and exudate.
5, in terms of bedridden patients with lupus nephritis should change position while giving the local massage.

Lupus kidney disease need to conduct an overall treatment

The treatment of lupus kidney disease is a very difficult thing, but so far no specific treatment such as medication, hormone drugs will have a better effect. But the harm to patients is also relatively large. Therefore need to pay attention to prevent complicationsin the treatment of the disease process, and to maintain the effects of treatment.
1, the overall treatment, to prevent worse. Lupus kidney disease need to be the overalltreatment, not only for the treatment of a symptom. Because lupus is a systemic disease, so in control lupus nephritis at the same time, you should pay attention to protection of renal function and other vital organs such as heart, lung or brain treatment and protection.Any infection, sunlight, chemicals, contact or pregnancy can induce lupus activity. Female patients should avoid pregnancy, the disease is uncontrolled. Such as pregnancy mustalso must be under the guidance of a doctor.
2, to prevent complications. Relatively poor physical condition of lupus kidney disease,prone to a variety of complications. Lupus nephritis patients in the treatment process isprone to various complications such as infections, cardiovascular complications, femoral head necrosis, severe cases can be life threatening. Key to reducing complications, the key lies in the rational use of anti-lupus drug, regular follow-up to early detection and treatment. The use of large doses of medication, should be relatively isolated, not in public places, and attention to climate change. Fever and other symptoms of infectionand timely treatment.
Thus, it is difficult to present medical standards, in order to completely cure lupusnephropathy patients in the treatment of disease, not only to pay attention to the effects of treatment should also be concerned about the complications, based on the overalltreatment does not require complete cure, but to prevent the increase.

TCM treatment of lupus nephritis how

Western medicine is effective, and treatment characteristics for patients with kidney disease but the disadvantages of repeated illness, which bring great harm to the patient's physical and mental, so choose Chinese medicine treatment of kidney patientsin recent years more and more, Chinese medicine treatment of lupus kidneyinflammationeffect how to? Effective treatment of lupus nephritis. Lupus nephritis is an autoimmunedisease, its exact etiology is not entirely clear. Also need long term follow up for Chinese medical treatment, regular review to maintain the optimistic attitude, I would like todoctor's advice to actively cooperate with the treatment.
1, lupus nephritis treatment is effective in reducing the recurrence of lupus nephritis. Easyrecurrence of lupus nephritis, many kidney patients in the overworked, due to decreased resistance to infection and other incentives under the action of recurrent disease, lupus isactive again. Thus preventing the recurrence of lupus is the key to improved patient outcomes.
2, Chinese medicine treatment can reduce the side effects of hormones and immunosuppressive agents, and improve patients' quality of life. Variety of side effectswill occur in a process using hormones and immunosuppressive agents. In this process,and with the use of Chinese medicine can significantly reduce these side effects,improve patient symptoms, improve the quality of life of patients with lupus nephritis.Lupus nephritis, the best approach to Chinese medicine treatment to avoid some side effects of Western medicine.
3, can also promote the remission of lupus nephritis. Syndrome differentiation oftraditional Chinese medicine, Chinese medicine practitioners believe that at this time of the pathogenesis of flaming toxic heat, blood stasis obstructing the network-basedkidney disease treatment should be Qingrejiedu Huoxuetongluo. The best of traditional Chinese medicine treatment for lupus nephritis kidney disease treatment, more effective control of lupus nephritis

Lupus nephritis diet low pay attention to

Lupus nephritis has been no stranger to the people. Lupus nephritis diet low pay attention!Lupus nephritis diet become an important means of adjuvant therapy. Here wemake a simple introduction for lupus nephritis diet.
1, lupus nephritis should be low-fat diet: in patients with systemic lupus erythematosusactivity, poor digestive function, Yichi light digestible food unfit for human consumptioncontaining more fat greasy food.
2, lupus nephritis should be low-sugar diet: systemic lupus erythematosus patients with long-term use of glucocorticoid, could easily cause a steroid diabetes and Cushing's syndrome, it should be appropriate to control appetite, eat less sugar content of foods that are high.
3, lupus nephritis should be low-salt diet: corticosteroids, or patients with kidney damageeasily lead to water and sodium retention, causing edema, so the low-salt diet. Lupus nephritis in patients with eating three low pay attention to: the attention to low-fat, low sugar, low salt, so as to in the Oh options to ensure the treatment effect in the correct premise.
Need to be reminded fighter yes, some patients Yichi patients with lupus nephritiscauses and circumstances vary, and some food, some patients should not eat. Best toconsult a specialist before eating.

Lupus nephritis treatment

Lupus nephritis treatment? Experts pointed out that in the course of treatment of lupus nephritis, regardless of the use of Chinese medicine for treatment, or the use of Western medicine to implement the treatment, treatment should be obtained through the followingways:
, Vasodilators: vasodilator purpose is to try to improve the state of the system of thekidney blood circulation blood to alleviate renal inherent cell ischemia and hypoxia,provide a good environment for the next repair of epithelial cells and mesangial cells.
2, anti-inflammatory: The aim is to reduce the infiltration of inflammatory cells, reducere-injury of glomerular epithelial cells.
3, anticoagulation: main in order to reduce the pressure of thrombosis, in order to lay the foundation for the repair of epithelial cells.
4, degradation: mainly excreted with the urine in order to make clear the immune complexes and the extracellular matrix.
Lupus nephritis treatment? Glomerular capillary epithelial cells will be fixed through the rational application of these four treatments, its normal physiological function of natural recovery. Epithelial barrier function will receive a reply, after the recovery of thesefunctions, protein and other clinical symptoms also vanish.

Lupus nephritis, kidney damage manifested

About 70% of patients with varying degrees of renal damage in the clinical manifestations of varying degrees of proteinuria, microscopic hematuria is more common, often accompanied by tubular urine and renal function impairment. The majority of patients with renal impairment to a lesser degree. Some patients although the clinical symptoms, but are not the development of renal insufficiency. Only a small number of renal damage in patients with renal failure. Hypertension is often associated with renal failure extent, become an important factor affecting prognosis. (A) asymptomatic proteinuria and (or) the hematuria type: This type is more common.Mainly for light - moderate proteinuria (<2.5g or (and) hematuria. (B) type of acute nephritic syndrome: rare, clinical manifestations resembles a post-streptococcal acute nephritis. (C) rapidly progressive glomerulonephritis syndrome type: rare, clinically resembles rapidly progressive glomerulonephritis. Characterized by three months, serum creatinine increased by ≥ 1 times. Uremia occurred within weeks to months. (D) The nephrotic syndrome: This type is common, accounting for about 2/3, but not necessarily with hyperlipidemia. When not in treatment, the majority of 2 to 3 years to uremia. This type is often confused with primary nephrotic syndrome, it is noteworthy. (E) chronic nephritic syndrome: the performance of sustained proteinuria, hematuria, urinary tube, and varying degrees of edema, hypertension, anemia and renal insufficiency. Course of a long, delayed healing, and thus occurrence of uremia. (F) a small number of patients can be manifested as chronic tubule interstitial nephritis clinical manifestations of patients with clinical manifestations of the specific gravity and (or) reduce the osmotic pressure, nocturnal enuresis, high or hypokalemia and other electrolyte disorders. End-stage lupus nephritis uremia, the patient's clinical activities (including serology) may disappear or become typical.

Systemic manifestations of lupus nephritis

The most common systemic manifestations of lupus nephritis with unexplained fever, arthritis, and skin and mucous membrane damage. The system is accompanied by involvement of the liver, heart, central nervous system and blood-forming organs, more than 1/3 of patients with polyserositis (pleural and pericardial).
(A) General symptoms: Most patients showed generalized weakness, weight loss, 90% of patients have fever, some more than 39 ° C.
(B) of the skin, mucous membrane damage: The majority of patients the skin is exposed at the skin lesions, about half of patients with facial butterfly erythema, or hair loss.Visible urticaria in some patients, discoid erythema, the palm of your hand, refers to nail week erythema, purpura. Some patients with oral ulcers. These hair loss as the main indicators of the SLE disease activity.
(C) of the joints and muscles: 90% of patients with joint pain, common to the small joints in the limbs. About 30% of patients with muscle pain. Large quantities of irregular use of hormones can lead to some patients with aseptic necrosis of femoral head.
(D) cardiovascular: some patients can occur in pericarditis, generally short and mild, a few may occur in patients myocarditis performance. About 1/4 patients, there may be Raynaud's phenomenon.
(Five lung and pleura: Some patients may have pleurisy or lupus pneumonitis. But a common clinical SLE complicated infection caused by pneumonia, rather than lupus pneumonitis, should be noted.
(F) the blood system: ① red blood cells: 50% ~ 75% of patients showed positive pigment cell anemia; ② The white blood cells: 60% of the patients white blood cell count <4.5 x 109 / L, in particular, is the lymph decreased more significantly; ③ platelet: general slightly lower, a few can be severely reduced. Approximately 50% of patients with lymph node enlargement.
(G) the gastrointestinal tract: abdominal pain, may be associated with abdominal organ lesions caused by vasculitis. Liver, splenomegaly were found in 30%, 20% of patients.The small number of patients with ascites.
(H) of the nervous system: clinical manifestations of complex and diverse, of varying severity. Often show mental disorders such as depression, mental confusion, pay attention to the spirit and hormone-induced abnormal differentiated. The most notable is the epilepsy (15% ~ 50%), and the occasional migraine, peripheral neuritis.

Lupus nephritis need chemotherapy?

Lupus nephritis in systemic lupus erythematosus renal different pathological types ofimmune damage is accompanied by obvious clinical manifestations of a disease ofkidney damage.
Lupus erythematosus is an autoimmune disease, the onset is slow, insidious occurrence of clinical manifestations are diverse and changeable. The disease can affect multiple systems of the body, multi-organ, can find a variety of autoantibodies in the patient's blood and organs. One of the autoimmune disease lupus erythematosus is a connective tissue disease range is divided into discoid lupus erythematosus (DLE), systemic lupus erythematosus (SLE), subacute cutaneous lupus erythematosus, lupus erythematosus and other types of deep.
Lupus nephritis need chemotherapy? How to be treated?
Lupus nephritis does not require chemotherapy medication principle is
1.Early oral steroid-based adjuvant drugs.
2.The standard amount of hormone invalid switch to the impact of hormone therapy.
3.The standard amount of hormone added azathioprine plus tripterygium film.
4.Infection with antibiotics.
5.Plasma exchange or dialysis therapy.
6. A kidney transplant.
7.Conditional should biopsy, pathological basis to guide therapy.

Lupus nephritis kidney damage performance

Symptoms of lupus erythematosus kidney damage is almost a series of symptoms, including glomerular, tubulointerstitial, renal vascular disease, can also be abrupt onset can be insidious, the course is generally longer, with or without symptoms, can also be kidney damage as the only clinical manifestations. Edema is a common clinical manifestations tend to be the main reason for patients attending. The increase in nocturnal enuresis is one of the early symptoms often reflect the urinary concentration of dysfunction. About 1/6 patients with varying degrees of renal insufficiency at the time of diagnosis. According to its clinical manifestations can be divided into the following type:

    Asymptomatic proteinuria (1) or (and) the hematuria type: This type is more common, edema, hypertension, mild to moderate proteinuria (<2.5g / d) or (and) hematuria.

    (2) type of acute nephritic syndrome: rare, clinically resembles streptococcal infection, acute nephritis, acute onset of hematuria, proteinuria, urinary tube, may have edema, hypertension, and even acute renal decline.

    (3) rapidly progressive glomerulonephritis syndrome, type: rare, clinically resembles rapidly progressive glomerulonephritis, abrupt onset and rapid development of oliguria or anuria, hematuria, proteinuria, urinary tube, can be edema, often without high blood pressure or mild hypertension, rapidly deteriorating rapidly and the development of anemia and hypoproteinemia, renal function, uremia in the weeks and months.

    (4) nephrotic syndrome: This type is common, about 60% of patients with renal impairment performance for this type. The clinical manifestations of massive proteinuria (3.5g / d) and hypoproteinemia, severe edema, but not necessarily have high cholesterol.If not treated, the majority of 2 to 3 years, the development of uremia. This type is easy to be confused with primary nephrotic syndrome, it is noteworthy.

    (5) type of chronic nephritic syndrome: the performance of persistent proteinuria, hematuria, urinary tube, and varying degrees of edema, hypertension, anemia and renal insufficiency. Course of a long, delayed healing and poor prognosis.

    (6) The type of renal tubular syndrome: a rare renal tubular acidosis, nocturia, edema, hypertension, increased urine β2-microglobulin, half of the patients with renal dysfunction.

    (7) clinical "silence": the clinical symptoms and signs had no kidney involvement, performance, urine tests negative, but the pathological examination (particularly in the electron microscopy and immunofluorescence) positive.

What are the extra-renal manifestations of lupus nephritis?

Systemic lupus erythematosus is a common disease can occur at any age and sex, is common in young women, the most common 20 to 30 years. Extrarenal manifestations are:
(1) General symptoms: Most patients showed generalized weakness, weight loss, 90% of patients have fever, heat-type variable, 40% more than 39 ℃.
(2) skin and mucous membranes: 50% of patients, there may be facial butterfly erythema, lesions confined to the two cheeks and the nose bridge, was mild edema and erythema, telangiectasia and scaly blisters, severe exudative inflammation and crusts, erythema subsided in general does not leave scars and pigmentation. The hair loss seen in 50% of patients, is a sensitive indicator of lupus activity. Livedo reticularis is common, is a typical characteristic of vasculitis. Many symptoms of the nervous system. In addition, also visible urticaria, Discoid erythema, A Zhou erythema, purpura, crack haemorrhage, oral and nasal ulcers.
(3) joint and muscle: 90% of patients with joint pain, common in the limbs, joints, about 10% of patients may have mild joint deformity, but generally no bone erosion signs.Long-term, large, irregular use of hormones, can lead to some patients with aseptic necrosis of femoral head.  1/3  of patients with muscle pain, and some even appear obvious symptoms of muscle weakness or muscle atrophy.
(4) cardiovascular: up to 2/3 of patients with active lupus erythematosus pericarditis cases, usually short and mild clinical manifestations. 10% of patients with myocarditis.Mitral and aortic valve may also be involved, generally at the apex and the heart at the bottom of smell and systolic murmur, which may also be related to anemia, tachycardia, or fever, diastolic murmur rare. There is also the Raynaud's phenomenon (25%), pulmonary hypertension and recurrent thrombophlebitis, which can be lupus erythematosus in the first symptom.
(5), lung and pleura: 40% ~ 46% of patients can occur in pleurisy, it is a reliable indicator of lupus erythematosus forthcoming involving the kidneys. Acute lupus pneumonitis and rare, difficulty breathing, chest pain and cough, and severe cases, massive hemoptysis, and some patients present with recurrent pulmonary atelectasis, a few may develop as diffuse interstitial pulmonary fibrosis.
(6) the blood system: 50% ~ 75% of the patients showed positive pigment cell anemia; 60% of patients with white blood cells <4.5 × 109 / L; platelet is generally slightly lower, a small number of <30 × 109 / L (approximately 50% ).
(7) of the gastrointestinal tract: some patients have nausea, vomiting, abdominal pain is common (approximately 50%) may be associated with peritonitis and abdominal viscera. Liver, splenomegaly were found in 30% and 20% of patients.
(8) of the nervous system: the incidence of symptoms and signs of about 50% to 60%, complex and diverse clinical manifestations, and manifests itself as mental disorders such as depression, mental confusion. Or epilepsy, migraine, paralysis, chorea, peripheral neuropathy and retinopathy.
(9) Other: menstrual irregularity, premenstrual symptoms increased, especially migraine. Some patients may occur painless lymph nodes, parotid gland swelling, conjunctivitis.

No clinical manifestations of renal biopsy in lupus nephritis how to infer the pathological type?

A definite link between the clinical manifestations and pathological changes in lupus nephritis. In general, the clinical manifestations of the normal glomerular and Department of membranous glomerulonephritis lighter, no urine abnormalities, can also be expressed as a latent nephritis; focal segmental proliferative glomerulonephritis type more than to hide nephritis, or chronic nephritis, a few can be manifested as nephrotic syndrome; diffuse proliferative nephritis was manifested as nephrotic syndrome (about 75%) and chronic nephritic syndrome; membranous lupus nephritis more performance for the nephrotic syndrome, but generally no significant hypertension, slow deterioration of renal function. At present, most scholars believe that the WHO histological type of limited value in the treatment and prognosis of lupus nephritis. However, in recent years, some scholars believe that the renal activity index and the chronic index important guiding treatment and prognosis. The activity index is defined by the representative of the activity of (potentially reversible) damage the ratings of those items, the sum of the percent of the total number of these projects include capillary proliferation, leukocyte infiltration, capillary wall destruction, nuclear condensation, cell crescent, platinum ear, transparent thrombosis, fibrin thrombus and cellulose deposition, interstitial cellular infiltration, acute tubular necrosis, vasculitis, according to the light of the various lesions, weight rated as 1, 2, 3 . The chronic Index is a total number of chronic sclerosing, atrophic and / or fibrosis score together, these projects include glomerular sclerosis, cellulose crescents and adhesions, interstitial sclerosis, tubular atrophy, arterial and arteriosclerosis, the light, re-rated as 1, 2, 3. Chronic index with advanced kidney disease was positively correlated. Activity in mild to moderately elevated prompt condition reversible after appropriate treatment, renal function improved or stable.Chronic index moderately elevated activity index moderately elevated, and still is a strong indication of the treatment. Severe activity index increased, the indication for active treatment, but it reflects the glomerular structure of severe, active destruction, can often lead to scar formation.

Lupus nephritis acupuncture

Acupoints are divided into two groups.
Group A: Wind pool, so Jiaji chest, chest, chest 11, the full three years;
Group B: Ojo, gu, Jiaji chest, chest 9, waist 1, multiple slip. Acupuncture three times aweek.
These two sets of acupuncture points are used interchangeably, 10
For a course of treatment, usually for three courses. For SIE therapy.

Lupus nephritis patients how to self-care?

(1) diet; patients with lupus nephritis adequate intake of nutrients such as protein, vitamins, mineral
Material, light is appropriate. Water, the salt should be moderate restrictions. Avoid a lot of tobacco, alcohol or irritating foods. Osteoporosis using vitamin D.
(2) Sports: Sports can promote blood circulation, improve heart and lung function,maintain muscle, bone toughness, have the benefit of any person, lupus patients is no exception. (Walking qigong) do not fatigue. Inflammation of the joints are not suitable foractivities.
(3) to avoid the sun: the lupus patients sensitive to the sun, caused by the wavelength ofultraviolet beta, should try to avoid sunshine.
(4) Prevention of infection: the impact of patients due to side effects of the impact of thedisease or steroids or immunosuppressive agents, a general decline in immunity is verysusceptible to bacterial violations caused by the infection of various organs. Commonrespiratory tract infections, urinary tract infections, gastrointestinal infections, and woundinfection.
(5) emotional adjustment: patients with sudden situations are diagnosed with lupus, is a heavy blow to the spiritual, often depression, anxiety, depression, anger, sin, denial,depression, and then the bell comes. But the emotions and disease has a close, mutualrelationship. Patients are faced with physical and mental challenges. To win the war, to maintain a pleasant mood, and contribute to the improvement of the disease. At the same time friends and family to give care and support.

Chinese medicine treatment of lupus nephritis

The ① toxic heat flaming: Zheng Jian fever subside, bleeding tendency, thirst for cold drinks, and even the faint delirium convulsions, or see the joint swelling and pain, redpurple, pulse loud or the number. The Expelling detoxification, cooling Xiaoban, side withrhino
The angle Di Huang Tang flavors xiaoduyin addition and subtraction. See comadelirium, available Angongniuhuang, Zixue; convulsions plus the antelope powder, Uncaria, Scorpion; joint swelling and pain the available Xuanbi Decoction.
② liver and kidney: two eyes dry, dysphoria hot, dry mouth and throat, hair off teethshake, waist and knee pain, dry stool, or low-grade fever night sweats, red urine, burning, dizziness, tinnitus, red tongue, thin pulse number. Expelling nourish hepatorenal sideGuishao yellow soup or Qijudihuang, Decoction. Urine hot hematuria, can be used to know Bo Di Huang Tonga verbena, Biota orientalis, the size of thistle; if dizziness, ringing in the ears, and silkworm, chrysanthemum, magnets.
③ spleen deficiency: Zheng Jian malaise, less gas lazy words, aversion to cold, weak waist, heel pain, pay less bloating, loose stools, clear urine, or edema, pale tongue with teeth marks. white coating, pulse delay weakness. Expelling Warming spleen, in the absence of edema, available soup of Xiangsha Liujunzi or Buzhongyiqi Tonga aconite,cinnamon, Curculigo, Epimedium; if the edema, partial Spleen virtual real spleendecoction, partial deficiency Zhenwu Tonga Achyranthes, Plantago. Indulge in the spleen and kidney qi deficiency are Jianpiyishenfang mainly spleen deficiency obvious, Bu Zhong Yi Qi Tang or different power Powder Plus laevigata, dodder seed, psoralen;edema in serious cases, Fangjihuangqi Tang Chun Ze Tang; kidney deficiency obviouslycan be used to Wu Zi Yan Zong Wan Codonopsis, Astragalus.
The ④ Qiyinliangxu: Zheng Jian languid, less gas lazy words, spontaneous perspiration,fear the wind, common cold, fever night sweats, five upset hot, dry mouth and throat,tongue pink or reddish, with scalloped edges, moss thin white, thin veins or breakdown.Expelling Qi and yin, fried addition and subtraction with Shenqidihuang soup ornourishing. If you see the yin and yang can be used to Dihuangyinzi, or the Shenqi Guifuyellow Decoction.

Pathology of lupus nephritis

1 pathogenesis
Pathogenesis of lupus nephritis there is no affirmative, can be replicated, animal experiments and clinical results are consistent conclusion. At present, most scholars believe that some foreign antigen (eg, retrovirus) and endogenous antigen (such as DNA immunization needed protein, lymphocyte surface antigen) role in immune regulation dysfunction in patients with highly active proliferation of B lymphocytes to produce a large number of autoantibodies, and combined with the corresponding antigen to form immune complex deposition in the glomerulus is the main pathogenesis of lupus nephritis. DNA and glomerular basement membrane binding, and the cycle of anti-DNA antibodies in situ formation of immune complexes can also be involved in lupus nephritis. Complement component defects in red blood cells and phagocytosis of FC or C3b receptor density on the cell to reduce the clearance of immune complexes decreased ability to increase immune complex deposition in the tissues, increased tissue damage. Complement activation, chemokine formation, leukocyte aggregation, and then released a series of inflammatory mediators and cytokines, leading to inflammation and glomerular damage of small blood vessels. At the same time, the renal interstitial obvious leukocyte and macrophage infiltration, with intercellular adhesion molecule (ICAM) and MHC antigen.The severity of renal interstitial lesion is usually associated with glomerular lesions.Some patients mild glomerular lesions, mainly interstitial vascular disease.
(2) pathological changes
Due to the complexity of the pathogenesis of lupus nephritis, renal pathological changes also showed the diversity and varied, each patient's glomerular, tubulointerstitial and small blood vessels may appear different changes. Lupus nephritis histological changes in glomerular, tubulointerstitial and vascular changes also determine the prognosis of patients. Renal histopathological damage, depends largely on the number of antibody deposition and the intensity of the inflammatory response induced. Persistent antibody deposition, and continue to cause inflammation, eventually leading to irreversible damage. Pathological changes characterized by: wire ring lesions: electron microscopy and immunofluorescence under the sediments of a large number of endothelial endothelial sediment leaving the basement membrane thickening, is an important feature of lupus nephritis kidney damage; Hematoxylin bodies: the general anti-nuclear body in place to cause cell damage caused by the nuclear chromatin gathered together; necrotizing vasculitis: the arterioles and capillaries were cellulose necrosis; electron microscope, electron dense deposits, nuclear fragmentation, virus-like particles and inclusions; immunofluorescence: diffuse granular sediments, mainly IgG, C3.

The cause of lupus nephritis

Lupus nephritis cause of so far is difficult to determine, lupus nephritis, and genetic, viral infections, sex hormones and stress factors have great relevance.
1. genetic factors
Recent studies show that genetic factors play a decisive role in the pathogenesis of lupus nephritis. Patients with lupus nephritis may have a family history, and close relatives of high prevalence. HLA-DR2 positive rate was significantly higher than normal high the HLA the-DQW1, HLA-DQW2, HLA-B8 Proof of, but also more common. In addition, C2, C4, Clr, and Cls lack of susceptibility to lupus nephritis. In recent years, the development of the theory and technology of molecular biology, and deepen the lupus nephritis study of immunogenetics, suggesting that other than the MHC genes and other "autoimmune genes" may have a crucial role in lupus nephritis.
2. Sex hormones
In view of this disease women significantly outnumber men, and more in the incidence of reproductive age, suggesting that the estrogen and Benbingfasheng. Pregnancy can make half of the patients deteriorate. Lupus nephritis in experimental animals given estrogen made it worse, such as give androgen to reduce disease. Has been found that the patients both men and women, estrone hydroxylation products were increased, while testosterone decrease.
3. psychological factors
Some studies reveal that psychological stress can trigger lupus nephritis disease activity, but also may be caused by lupus nephritis. However, personality characteristics and stressful life events, intensity, duration, frequency and degree of the impact of stress on the responses of the individual by the individual quality.
4. environmental factors
(1) virus infection
Many scholars believe that this disease and slow virus (C-type RNA virus). Detection of type C RNA virus in New Zealand hybrid mice NZB/NAWF1 of organizations suffering from lupus nephritis, although the patient groups has not yet proven the existence of such viruses, but can be detected to engage in the RNA-DNA antibodies in serum.
(2) sunlight or ultraviolet radiation
Horn cells of the skin by ultraviolet light to stimulate the secretion of interleukins to stimulate B cells and induce T cells to produce interleukin-2 stimulates the immune system to disease progression. Some people think that the UV DNA is converted to thymine dimer, so that the antigen enhanced. Sunlight allergy seen in 40% of patients with lupus nephritis. Cold or strong electro-optical radiation can also induce or aggravate the disease.
In addition, certain drugs and food change and the occurrence of lupus nephritis.

The cause of lupus nephritis

This disease is the body's endogenous (self) antigen by the immune complex diseases and disorders associated with T cell function. To be investigated in the patients serum antibodies have a variety of anti-autologous tissue composition, including anti-DNA antibodies, especially anti-double stranded DNA (natural DNA) antibody is more effective than positive, patients with circulating immune complexes separable into natural and single-stranded DNA antibodies and antigens; eluted from glomerular immunoglobulin antibody combined with natural and single-stranded DNA antigen. A humoral immune changes in which DNA and anti-DNA antibodies form immune complexes play a major role. (1) virus triggering factors: more studies confirm the disease is an RNA virus - type C virus. C-type virus on the one hand may damage the cells, so that the release of DNA was highly immunogenic; the other hand, may be due to this virus reverse transcriptase, RNA replication of the virus itself into DNA, leaving the body to produce anti-DNA antibodies both anti-viral replication generated by DNA, but also anti-human DNA. (2) Bacterial toxins and lipopolysaccharide trigger factors: Some bacterial lipopolysaccharide composition injected into mice and observed that can contribute to the DNA of mouse tissue release to the blood circulation and the role of mitogen to promote the activation of B lymphocytes to produce antibodies, so that these substances promote the role of DNA antigen-antibody complex to generate. (3) release of DNA from tissue damage: the patients in vivo lymphocyte cytotoxic antibodies.Medium molecular weight soluble DNA immune complexes through the blood circulation to the kidneys (or other organs) and deposited in the glomerulus.
Cellular immunity: the suppressor T cell function and decline in the number. The reason is that serum cytotoxic antibody (anti-lymphocyte or thymocyte antibody), thereby undermining the T cells, suppressor T cells down the one hand, can directly reduce the inhibition of antibody formation, on the other hand may be due to the release of The lymphokines declined to inactivate the ability of helper T cells, helper T cells promote the ability to increase antibody production, total humoral immune (antibody formation) strong.
(3) genetic factors, family history of the same disease accounted for 0.4% to 3.4% in the patients.

Gender difference of lupus nephritis

Kidney disease and many aspects of our life, such as age, gender, race, occupation, genetic, environmental, infections, drugs, etc., which have a certain tendency of gender on the occurrence of some kidney disease.
Female patients more susceptible to lupus nephritis (male to female ratio of approximately 1:9), pyelonephritis (male to female ratio of approximately 1:8), male patients more susceptible to acute nephritis and nephrotic syndrome.
Why kidney disease showed that men and women do not?
This mainly involves two characteristics:
Physiological characteristics such as sex hormone differences; anatomical characteristics, such as urinary tract structural difference, but the exact cause is not entirely clear. In outpatient visits, pyelonephritis, acute nephritis and nephrotic syndrome are easily diagnosed, lupus nephritis and nephritis and nephrotic syndrome susceptible to wrong diagnosis or missed diagnosis, and ultimately lead to delays in treatment.Therefore, female patients with nephritis or nephrotic syndrome, should be noted that the presence of lupus nephritis.
Lupus nephritis
Lupus nephritis is the result of invasion of kidneys of systemic lupus erythematosus. All likelihood occur in young women. The incidence of familial tendency in some patients, some patients by ultraviolet radiation, viral infection or pregnancy and after childbirth the body's immune dysfunction, resulting in a series of autoantibodies caused by the occurrence of the disease. Its symptoms in three aspects:
Systemic manifestations: intermittent fever; malar rash shaped like a butterfly, also known as the butterfly erythema; painless oral ulcers; multiple joint swelling and pain; epilepsy or mental disorders; hand, foot and cold become pale, warm turned purple, followed by recovery of the regular color, also known as Raynaud's phenomenon.
Renal manifestations: hematuria or proteinuria; hematuria, proteinuria, with edema, backache, or high blood pressure, nephritis-like performance; massive proteinuria, hypoalbuminemia, edema, nephrotic syndrome-like performance; hematuria. proteinuria with renal sharp decline, showing a rapidly progressive glomerulonephritis performance; performance of chronic renal failure. Life can be expressed as one of the cases.
3 laboratory abnormalities: blood leukopenia (<4 × 109 / L), or anemia, or thrombocytopenia (<100 × 109 / L,); rapid erythrocyte sedimentation rate; complement C3 low; antinuclear antibodies and antibody-positive . Renal biopsy is not only helpful in diagnosis of lupus nephritis, the more clear the severity of kidney damage, to determine the condition and the correct treatment.
Sometimes it is not typical symptoms of lupus nephritis, only kidney abnormalities are often misdiagnosed as nephritis, nephrotic syndrome or chronic renal failure, missed the best timing of treatment, the disease can not be improved in time to bring uremia, heart failure or sepsis and other adverse consequences. Therefore, early diagnosis and early treatment is very important. Female kidney disease patients should self-examination whether the above-mentioned systemic symptoms, if present, should further the appropriate laboratory tests.

Type, various types of features and treatment of lupus nephritis

1, Ⅰ type of lupus nephritis (lupus nephritis type 1, 2)
Renal tissue of lupus nephritis type Ⅰ, light microscope, normal structure, immunoglobulin and complement deposition in the use of immunofluorescence. The prognosis of this type of lupus nephritis does not require special treatment, but still need follow-up study, to prepare for any eventuality.
Two, lupus nephritis type Ⅱ (lupus nephritis type 2, 2)
Lupus nephritis type Ⅱ, this type of kidney damage in the glomerular mesangial area, which no mesangial cell proliferation is known as type Ⅱ A, the prognosis of such mild mesangial lesions without treatment; II B-type lesions mesangial seen the proliferation of mesangial cells and monocytes, accompanied by proteinuria 1g/24h and low complement C3 hyperlipidemia in the treatment of six weeks of treatment between -3 and generally use strong pine 20mg / d, after with the improvement in reduction of the disease remain. Lupus nephritis type Ⅱ, interstitial and vascular damage.
3, type Ⅲ and type Ⅳ of lupus nephritis (lupus nephritis type 3, 3 and 4, 4)
Ⅲ type of glomerular damage in lupus nephritis has been more significant, In addition to the mesangial focal stage glomerular capillary has been involved, but no more than 50% of the total glomerular Lupus nephritis type Ⅳ and Ⅲ type of the type of injury, the only damage the broader reach more than 50% of glomerular damage, and even more serious degree.
Pathological damage similar between the two treatment programs similar prognosis.The development of these two types of lupus nephritis in 10 years to up to 50% of ESRD, but also to strengthen the treatment to prolong the survival period of patients with both types of a very important point. Usually in the prognosis of treatment with glucocorticoids and cytotoxic drugs. The glucocorticoid prednisone-based, conventional dosage is to be carried out under the guidance of a doctor, and the need to maintain a specific time we must obey the doctor's orders. If necessary time to give methylprednisolone maintenance treatment, this effect is better, and minimal side effects. Cell poison drug is also commonly used treatment, glucocorticoid with the cell poison, drug combination more fully. But the cytotoxic onset interval is longer, often 3-4 months before onset.
4, lupus nephritis type Ⅴ
Ⅴ type of lupus nephritis is divided into four types, type Ⅴ, a comparison with idiopathic membranous nephropathy; type Ⅴ b diffuse mesangial changes; type Ⅴ c segmental proliferation or segmental sclerosis; V d-exist with diffuse proliferative glomerulonephritis of this type regardless of the clinical manifestations of organizational performance is similar to the type Ⅴ lupus nephritis.
This type of treatment of lupus nephritis to distinguish between what are membranous lupus nephritis or diffuse lupus nephritis, using different pathological drugs and treatment methods are very different, but also on the type of symptomatic treatment.
5, lupus nephritis type Ⅵ
Ⅵ type of lupus nephritis belong to the late lupus nephritis, but accounts for only 2% of all lupus nephritis type.

Type, various types of features and treatment of lupus nephritis

1, Ⅰ type of lupus nephritis (lupus nephritis type 1, 2)
Renal tissue of lupus nephritis type Ⅰ, light microscope, normal structure, immunoglobulin and complement deposition in the use of immunofluorescence. The prognosis of this type of lupus nephritis does not require special treatment, but still need follow-up study, to prepare for any eventuality.
Two, lupus nephritis type Ⅱ (lupus nephritis type 2, 2)
Lupus nephritis type Ⅱ, this type of kidney damage in the glomerular mesangial area, which no mesangial cell proliferation is known as type Ⅱ A, the prognosis of such mild mesangial lesions without treatment; II B-type lesions mesangial seen the proliferation of mesangial cells and monocytes, accompanied by proteinuria 1g/24h and low complement C3 hyperlipidemia in the treatment of six weeks of treatment between -3 and generally use strong pine 20mg / d, after with the improvement in reduction of the disease remain. Lupus nephritis type Ⅱ, interstitial and vascular damage.
3, type Ⅲ and type Ⅳ of lupus nephritis (lupus nephritis type 3, 3 and 4, 4)
Ⅲ type of glomerular damage in lupus nephritis has been more significant, In addition to the mesangial focal stage glomerular capillary has been involved, but no more than 50% of the total glomerular Lupus nephritis type Ⅳ and Ⅲ type of the type of injury, the only damage the broader reach more than 50% of glomerular damage, and even more serious degree.
Pathological damage similar between the two treatment programs similar prognosis.The development of these two types of lupus nephritis in 10 years to up to 50% of ESRD, but also to strengthen the treatment to prolong the survival period of patients with both types of a very important point. Usually in the prognosis of treatment with glucocorticoids and cytotoxic drugs. The glucocorticoid prednisone-based, conventional dosage is to be carried out under the guidance of a doctor, and the need to maintain a specific time we must obey the doctor's orders. If necessary time to give methylprednisolone maintenance treatment, this effect is better, and minimal side effects. Cell poison drug is also commonly used treatment, glucocorticoid with the cell poison, drug combination more fully. But the cytotoxic onset interval is longer, often 3-4 months before onset.
4, lupus nephritis type Ⅴ
Ⅴ type of lupus nephritis is divided into four types, type Ⅴ, a comparison with idiopathic membranous nephropathy; type Ⅴ b diffuse mesangial changes; type Ⅴ c segmental proliferation or segmental sclerosis; V d-exist with diffuse proliferative glomerulonephritis of this type regardless of the clinical manifestations of organizational performance is similar to the type Ⅴ lupus nephritis.
This type of treatment of lupus nephritis to distinguish between what are membranous lupus nephritis or diffuse lupus nephritis, using different pathological drugs and treatment methods are very different, but also on the type of symptomatic treatment.
5, lupus nephritis type Ⅵ
Ⅵ type of lupus nephritis belong to the late lupus nephritis, but accounts for only 2% of all lupus nephritis type.

What is lupus nephritis?

Systemic lupus erythematosus (with systemic lupus erythematosus, systemic lupus erythematosus) is a multi-system involving the whole body, multi-organ with a variety ofautoantibodies in autoimmune diseases. Lupus nephritis (lupus Nephritis, lupus nephritis) isthe most common and most serious complications of systemic lupus erythematosus.Serious kidney complications can be directly or indirectly affect the survival rate of patientswith systemic lupus erythematosus. One of the leading cause of death in this disease.