Laboratory tests of systemic lupus erythematosus

First, the general inspection
One. Blood can have three lines of pancytopenia
(2) urine proteinuria, hematuria, urinary tube
3 ESR often faster
Second, autoantibodies
(A) anti-nuclear body (ANA) and ANA spectrum
1. The ANA: anti-nuclear antigen composition of autoantibodies general, more than 90% of SLE patients with positive screening test for SLE,; the ANA alternative inspection of LE cells; specific for SLE.
(2) Anti-nucleosome antibody spectrum (ANA spectrum)
ANA by more than 10 types of autoantibodies, become ANA spectra:
Insoluble ingredients (1) anti-nuclear antibody:
1 anti-double stranded DNA antibodies (anti-ds-DNA antibody) specific antibodies in SLE, and its titer correlated with SLE disease activity is positively correlated, anti ds-DNA antibodies may predispose to lupus nephritis
② anti-histone antibodies (AHA): drug-induced lupus more than 95% positive.
(2) soluble ingredients of the anti-nuclear antibody (anti-ENA antibodies) to extractable nuclear antigens (ENA) with saline acidic nuclear protein extracted from the nucleus such as animal liver and spleen. Anti-extractable nuclear antigen antibody called anti-ENA antibodies, the current commercially available anti-ENA antibody test kit includes the following test items:
1 antibody anti-Sm (Smith)
②. Anti-RNP (anti-ribonucleoprotein) antibodies
③ anti-SSA antibody (anti-Ro antibodies)
④ The anti-SSB antibodies (anti-La antibodies)
⑤ The anti-r-RNP (anti-ribosomal) antibody
⑥. Anti-Jo-1 antibody (see Dermatomyositis)
⑦ anti-Scl-70 antibody (see scleroderma)
(B) of antiphospholipid antibodies
(1) anticardiolipin antibody (ACL antibodies)
2 VDRL false-positive
(3) Lupus anticoagulant (LAC)
Antiphospholipid syndrome: seen in habitual abortion, arterial and venous thrombosis and thrombocytopenia
(C) rheumatoid factor (RF): in patients with SLE can be positive
(D) other autoantibodies
An anti-histone antibody (AHA), see above
Anti-RBC membrane antibodies, such as (Coombs, 'test positive)
(3) platelet-associated antibody (PAIgG)
Anti-lymphocyte membrane antibody
Anti-neuronal antibodies - lupus encephalopathy
Third, the complement
Reduce the total complement (CH50) and C3, C4, suggesting lupus activity
Lupus band test (LBT): hair detection by immunofluorescence in the epidermis and dermis of the skin at the junction of the deposition of blue green fluorescence (immunoglobulin)
Renal biopsy: can the diagnosis of SLE can be pathological type
Six other tests (such as head CT lung X-ray plain film heart ultrasound).