Gender difference of lupus nephritis

Kidney disease and many aspects of our life, such as age, gender, race, occupation, genetic, environmental, infections, drugs, etc., which have a certain tendency of gender on the occurrence of some kidney disease.
Female patients more susceptible to lupus nephritis (male to female ratio of approximately 1:9), pyelonephritis (male to female ratio of approximately 1:8), male patients more susceptible to acute nephritis and nephrotic syndrome.
Why kidney disease showed that men and women do not?
This mainly involves two characteristics:
Physiological characteristics such as sex hormone differences; anatomical characteristics, such as urinary tract structural difference, but the exact cause is not entirely clear. In outpatient visits, pyelonephritis, acute nephritis and nephrotic syndrome are easily diagnosed, lupus nephritis and nephritis and nephrotic syndrome susceptible to wrong diagnosis or missed diagnosis, and ultimately lead to delays in treatment.Therefore, female patients with nephritis or nephrotic syndrome, should be noted that the presence of lupus nephritis.
Lupus nephritis
Lupus nephritis is the result of invasion of kidneys of systemic lupus erythematosus. All likelihood occur in young women. The incidence of familial tendency in some patients, some patients by ultraviolet radiation, viral infection or pregnancy and after childbirth the body's immune dysfunction, resulting in a series of autoantibodies caused by the occurrence of the disease. Its symptoms in three aspects:
Systemic manifestations: intermittent fever; malar rash shaped like a butterfly, also known as the butterfly erythema; painless oral ulcers; multiple joint swelling and pain; epilepsy or mental disorders; hand, foot and cold become pale, warm turned purple, followed by recovery of the regular color, also known as Raynaud's phenomenon.
Renal manifestations: hematuria or proteinuria; hematuria, proteinuria, with edema, backache, or high blood pressure, nephritis-like performance; massive proteinuria, hypoalbuminemia, edema, nephrotic syndrome-like performance; hematuria. proteinuria with renal sharp decline, showing a rapidly progressive glomerulonephritis performance; performance of chronic renal failure. Life can be expressed as one of the cases.
3 laboratory abnormalities: blood leukopenia (<4 × 109 / L), or anemia, or thrombocytopenia (<100 × 109 / L,); rapid erythrocyte sedimentation rate; complement C3 low; antinuclear antibodies and antibody-positive . Renal biopsy is not only helpful in diagnosis of lupus nephritis, the more clear the severity of kidney damage, to determine the condition and the correct treatment.
Sometimes it is not typical symptoms of lupus nephritis, only kidney abnormalities are often misdiagnosed as nephritis, nephrotic syndrome or chronic renal failure, missed the best timing of treatment, the disease can not be improved in time to bring uremia, heart failure or sepsis and other adverse consequences. Therefore, early diagnosis and early treatment is very important. Female kidney disease patients should self-examination whether the above-mentioned systemic symptoms, if present, should further the appropriate laboratory tests.