The cause of lupus nephritis

Lupus nephritis cause of so far is difficult to determine, lupus nephritis, and genetic, viral infections, sex hormones and stress factors have great relevance.
1. genetic factors
Recent studies show that genetic factors play a decisive role in the pathogenesis of lupus nephritis. Patients with lupus nephritis may have a family history, and close relatives of high prevalence. HLA-DR2 positive rate was significantly higher than normal high the HLA the-DQW1, HLA-DQW2, HLA-B8 Proof of, but also more common. In addition, C2, C4, Clr, and Cls lack of susceptibility to lupus nephritis. In recent years, the development of the theory and technology of molecular biology, and deepen the lupus nephritis study of immunogenetics, suggesting that other than the MHC genes and other "autoimmune genes" may have a crucial role in lupus nephritis.
2. Sex hormones
In view of this disease women significantly outnumber men, and more in the incidence of reproductive age, suggesting that the estrogen and Benbingfasheng. Pregnancy can make half of the patients deteriorate. Lupus nephritis in experimental animals given estrogen made it worse, such as give androgen to reduce disease. Has been found that the patients both men and women, estrone hydroxylation products were increased, while testosterone decrease.
3. psychological factors
Some studies reveal that psychological stress can trigger lupus nephritis disease activity, but also may be caused by lupus nephritis. However, personality characteristics and stressful life events, intensity, duration, frequency and degree of the impact of stress on the responses of the individual by the individual quality.
4. environmental factors
(1) virus infection
Many scholars believe that this disease and slow virus (C-type RNA virus). Detection of type C RNA virus in New Zealand hybrid mice NZB/NAWF1 of organizations suffering from lupus nephritis, although the patient groups has not yet proven the existence of such viruses, but can be detected to engage in the RNA-DNA antibodies in serum.
(2) sunlight or ultraviolet radiation
Horn cells of the skin by ultraviolet light to stimulate the secretion of interleukins to stimulate B cells and induce T cells to produce interleukin-2 stimulates the immune system to disease progression. Some people think that the UV DNA is converted to thymine dimer, so that the antigen enhanced. Sunlight allergy seen in 40% of patients with lupus nephritis. Cold or strong electro-optical radiation can also induce or aggravate the disease.
In addition, certain drugs and food change and the occurrence of lupus nephritis.